Wednesday, May 3, 2017

Overview

  • A malignant tumor of the cartilage
  • Most often seen as a mass of soft tissue with varying degrees of calcification, indistiguishable border with the bone of origin
  • Often greater than 4 cm at presentation (Limaiem et al. 2023)
  • Most cases are sporadic, most commonly seen above the age of 50 years (Limaiem et al. 2023).
  • The second most common bony malignancy (Weinschenk et al. 2021 and Chow 2018).
  • Late-recurrences not uncommon; histological grade is the most important predictor (Limaiem et al. 2023)

Radiologic Findings

  • On CT:
    • Non-contrast erosion of surrounding bone, ringed or crescent calcification in low grade lesions, amorphous calcification in high grade
    • Contrast shows heterogenous enhancement, ill-defined boders
  • On MR:
    • T1 shows homogenous isointense signal, bone invasion is well-noted as well as marrow replacement
    • T2 shows high signal with possible surrounding edema
    • T1 post-contrast shows varying enhancement, more with higher grade lesion
CT with Contrast
chondroSarc_CT_0727
ChondroSarc_CTcor_0727

 

T1-weighted MR
ChondroSarc_T2_0727

 

TI post-con fat-sat
ChondroSarc_T1post_0727

References

Limaiem F, Davis DD, Sticco KL. Chondrosarcoma. [Updated 2023 Aug 14]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK38132/

Weinschenk RC, Wang WL, Lewis VO. Chondrosarcoma. J Am Acad Orthop Surg. 2021;29(13):553-562. doi:10.5435/JAAOS-D-20-01188

Chow WA. Chondrosarcoma: biology, genetics, and epigenetics. F1000Res. 2018;7:F1000 Faculty Rev-1826. Published 2018 Nov 20. doi:10.12688/f1000research.15953.1